[대학원 생명과학과 세미나 안내]
연사 : Lee Seok-Yong 교수(Duke University School of Medicine)
연제 : Structural Basis of Cellular Nucleoside Transport
일시 : 2018년 8월 13일 (월) 오전 10시 30분
장소 : 하나과학관 A동 101호
초청교수 : 송현규 교수
Abstract
Nucleoside transporters (NTs) are integral membrane proteins that are designed to transport nucleosides into the cells of the human body. Nucleoside transport across cell membranes is physiologically important as it provides the major source of nucleosides for DNA/RNA synthesis in many cell types, and it is responsible for the termination of adenosine signaling. Furthermore, many nucleoside-derived anticancer and antiviral drugs are transported into cells by NTs. Despite their importance in physiology and pharmacology, the molecular mechanism of NTs was largely unknown due to the lack of atomic structures of NTs and structure-based mechanistic studies. My laboratory has contributed significantly to our understanding of the fundamental mechanism of selective nucleoside transport by concentrative nucleoside transporters (CNTs), one of the two major NTs in human, through structural and functional studies. We anticipate our findings will provide a complete description of nucleoside and nucleoside drug transport across the cell membrane by CNT, which eventually will facilitate the development of new therapeutic reagents.