[대학원 생명과학과 세미나 안내]
연사 : 권종범 교수(이화여자대학교 생명과학과)
연제 : SWI/SNF bromodomain inhibitor in cancer thearpy: from proof-of-concept to applications
일시 : 2018년 11월 9일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 강성만 교수
Abstract
Chemotherapy and radiotherapy treat cancer by inducing DNA-double strand break (DSB) in cancer cells using chemical drugs and ionizing radiation (IR), respectively. However, DNA repair pathway in cancer cells often leads to resistance and unsuccessful outcome in cancer treatment. Blocking of DNA repair pathway by targeting repair proteins can increase the sensitivity of cancer cells to chemical drugs and IR. The SWI/SNF chromatin remodeling complex promotes DSB repair and binding of BRG1, the catalytic subunit of SWI/SNF complex, to acetylated histones on DSB-surrounding chromatin via bromodomain (BRD) is critical for this activity. As a proof-of-concept study, we previously have shown that blocking chromatin binding of BRG1, the catalytic ATPase of SWI/SNF, by a dominant-negative activity of BRG1-BRD enhances the sensitivity of cancer cells to DNA damage, validating BRG1 BRD as a target for cancer therapy. I will present recent results from our laboratory showing that a small chemical compound that specifically inhibits the BRDs of BRG1 and some other subunits of SWI/SNF sensitizes cancer cells to DNA damage.