[대학원 생명과학과 세미나 안내]
연사 : 이재선 교수(인하대학교 의과대학)
연제 : Cellular senescence: signaling pathways and promising targets
일시 : 2018년 11월 23일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 고영규 교수
Abstract
Cellular senescence was originally characterized as a state of indefinite growth arrest. Accumulating evidences demonstrated that cellular senescence influences a variety of physiological and pathological processes, such as normal tissue homeostasis, cancer, and age-related diseases. In addition, it has been recently found that senescence is engaged in embryo development, tissue remodeling, immune response, and wound healing. It means that cellular senescence is a double-edged sword in tumor and tissue environments. We are trying to identify novel senescence regulatory molecules and their molecular action mechanisms involving in the cancer cell senescence during last 10 years. In this presentation, recent our research outcome in the field of cancer cell senescence will be presented. We revealed that the proper status of heparan sulfation in proteoglycan is essential for the prevention of cellular senescence. We found that integrin α6β4 is specifically activated and acts primarily to induce premature senescence, instead of apoptosis, in irradiated cancer cells. We identified novel RNA binding protein WIG1 and elucidated its function for regulation of either p21 or ACOT7 expression. In addition, we identified novel senescence-regulatory long intergenic noncoding RNA, Linc-ASEN and elucidated its molecular action mechanism in concert with UPF1 and PRC1/2 to regulate p21 expression, finally preventing cellular senescence. We believe that efforts for the better understanding of cancer cell senescence will improve the development of promising strategies for cancer treatment.