[대학원 생명과학과 세미나 안내]
연사 : 정희선 박사 (국립암센터 연구소)
연제 : Metabolism and Autophagy:Pathways for Potential Cancer Therapeutics
일시 : 2019년 1월 29일 (화) 오후 5시
장소 : 하나과학관 A동 109호
초청교수 : 최의주 교수
Abstract
Cancer cells undergo a wide range of metabolic reprogramming to take advantage for supporting rapid growth and survival. Autophagy plays a critical role in directly regulating cellular metabolism as a main catabolic process mediated by lysosomal degradation in response to the metabolic stress. During cancer development, autophagy plays opposite functions in suppressing or promoting tumors dependent of distinct stage. Autophagy maintains cellular homeostasis by degrading unnecessary cellular molecules and oncogenic products, thereby suppressing tumorigenesis. By contrast, autophagy enables to promote cancer growth in advanced tumor by supplying nutrients and relieving metabolic stress.
In this presentation, recent progress indicates that how autophagy is integrated with cellular metabolic alteration during cancer development. Multiple mechanisms would be suggested to explain the functions of autophagy at distinct stage of tumor progression. Caner metabolic alterations associated with autophagy can be determined by certain oncogenic activators and/or tumor suppressors. Understanding molecular mechanism of autophagy and metabolic alteration during cancer development may suggest potential targets for therapeutic intervention