[대학원 생명과학과 세미나 안내]
연사 : 박현우 교수 (연세대학교 생화학과)
연제 : Regulation of the Hippo Pathway in Cancer Biology
일시 : 2019년 5월 27일 (월) 오후 5시
장소 : 하나과학관 A동 101호
초청교수 : 최의주 교수
Abstract
The Hippo-YAP/TAZ Signaling Pathway have emerged as keyregulator of organ size and tissue homeostasis, and their dysregulationcontributes to human cancer. Here I will present an overview ofvarious upstream regulators of Hippo-YAP/TAZ and TEAD including Mechanotransduction,GPCR ligands, Cell Polarity, and Energy stress as potential targets foranticancer therapies. I will also focus on our recent findings on YAP/TAZ asbona fide effectors of the alternative Wnt signaling pathway. Wnt5a/b and Wnt3ainduce YAP/TAZ activation via the alternative Wnt pathway that is independentof Wnt/b-catenin signaling. In addition, we recently identified TAZ expressionin leukemia and macrophage cells in several pathologic contexts, which suggesta novel function of Hippo signaling in leukemogenesis and immunity. UnlikeYAP/TAZ, the transcription factor TEAD are constantly nuclear. However, our recent findings revealed that specificstress promotes cytoplasmic translocation of TEAD via protein-proteininteraction with p38 MAPK. Importantly, inhibition of TEAD by p38-induced cytoplasmictranslocation suppresses YAP/TAZ-driven cancer cell growth. Therefore, theHippo pathway is an attractive target for anticancer drug development.