[대학원 생명과학과 세미나 안내]
연사 : 윤상선 교수 (연세대 의과대학 미생물학교실)
연제 : Commensal-pathogen interactions inside host tissues
일시 : 2019년 11월 8일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 이은진 교수
Abstract
Due to the presence of indigenous microbes maintaining a complex self-regulating community inside the host tissues, infections are outcomes of multi-layered interactions between commensal microbes and pathogenic invaders. However, it remains unclear how modulations of the commensal microbiota composition affect host infection resistance. Here, we reveal that two commensal microbes, Bacteroides vulgatus and Staphylococcus epidermidis can exert protective effects against pathogenic infections in host intestine or airway, respectively. Bacteroides vulgatus, a dominant species of the Bacteroidetes phylum in mouse intestine, suppresses infection by Vibrio cholerae, an important human pathogen. The Bacteroidetes-depleted adult mice developed severe cholera-like symptoms, when infected with V. cholerae. Germ-free mice mono-associated with B. vulgatus became resistant to V. cholerae infection. Among forty nine S. epidermidis isolates from healthy human nasal cavity, one strain, named SE5, specifically and robustly inhibited airway infection by Pseudomonas aeruginosa, an important human airway pathogen in vivo. SE5 was found to produce a secretome, whose composition is distinct from other isolates of the same species. Detailed mechanisms of infection controls by these symbiotic microbes will be presented.