[대학원 생명과학과 세미나 안내]
연사 : 조계원 교수 (순천향 의생명연구원)
연제 : Adipose Tissue Immune Cells: Key players in Metabolic Diseases
일시 : 2019년 11월 29일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 구승회 교수
Abstract
Adipose tissue plays a crucial role in whole-body lipid and glucose metabolism. Dysfunction of adipose tissue such as lipodystrophy and obesity leads to metabolic diseases including insulin resistance and type 2 diabetes. Over the past few years, it has been established that chronic inflammation of hypertrophic adipose tissue depots in obese individuals leads to obesity-associated insulin resistance and is mediated by cells of the innate immune system, particularly adipose tissue macrophages (ATMs). More recently, cells of the adaptive immune system, T lymphocytes in adipose tissue (ATTs), have also emerged as important regulators of glucose homeostasis. However, it has been unresolved how ATMs interact with ATTs and the importance in generating adipose tissue inflammation and contributing glucose homeostasis. In this talk, novel mechanisms responsible for crosstalk of ATMs with ATTs during the development of obesity-induced inflammation and insulin resistance will be introduced. Second, I will provide the diabetic-specific and weight-cycling-specific characteristics of ATTs which would be the therapeutical target for obesity-associated metabolic diseases. More comprehensive model of immunometabolism will also be discussed.