[대학원 생명과학과 세미나 안내]
연사 : 이호 교수(국림암센터)
연제 : Regulation of Pluripotency and Differentiation in Mouse Embryonic Stem Cells
일시 : 2020년 4월 17일 (금) 오후 5시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 백자현 교수
Abstract
The actions of transcription factors, chromatin modifiers, and signal transduction are crucial for the programming of cell states. Although the importance of various epigenetic machineries for controlling pluripotency of embryonic stem (ES) cells has been previously studied, how chromatin modifiers cooperate with specific transcription factors still remains largely elusive. Recently we reported that Pontin chromatin remodeling factor plays an essential role as a coactivator for Oct4 for maintenance of pluripotency in mouse ES cells (Nat Commun, 2015). This report demonstrated that the Oct4-Pontin module plays critical roles in the regulation of genes involved in ES cell fate determination.
Next, we tried to identify another factors as regulators of pluripotency and differentiation in mouse embryonic stem cells. For this purpose, we collected genes whose knockout embryos show early lethality at the peri-implantation stage and investigated its function in regulating pluripotency and differentiation. Here, I will introduce these pluripotency factors and their roles.