[대학원 생명과학과 세미나 안내]
연사 : 김유진 박사(고대 의과대학 기초해부학교실)
연제 : Strategy for the production of genetically engineered mouse model
일시 : 2020년 5월 25일 (월) 오후 5시
장소 : 하나과학관 A동 207호
초청교수 : 박세호 교수
Abstract
A genetically modified mouse model is a mouse that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research of human diseases and drug development, and are also used for research of function of genes.
Multiple genetic modification techniques have been developed to modify mouse genomes. There are three representative technical approaches to produce genetically modified mice. The first approach is pronuclear injection into a single cell of the mouse embryo, where it will randomly integrate into the mouse genome. The second method is modifying embryonic stem cells with a DNA constructs containing DNA sequences homologous to the target gene. The last method is the genome editing system using engineered nucleases such as ZFN, TALEN, CRISPR/Cas9.