- 강연일시 : 2014. 9. 2 (화) / 오후 4:30 ~
- 장 소 : 생명과학대학 (녹지) 109호
- 연 사 : Derek B. Sant'Angelo (Associate Professor)
Rutgers-Robert Wood Johnson Medical School (RWJMS)
- 강연제목 : PLZF-dependent regulation of immune responses
- 문 의 : 박세호 교수 (교내 3160)
Heritable inactivation of Zbtb16 (PLZF) is induced during thymocyte development and is maintained in mature T cells
Sai Zhang1,4, Amale Laouar2,4 Lisa K. Denzin1,3,4 and Derek B. Sant’Angelo1,3,4
1Graduate School of Biomedical Sciences
2Department of Surgery
3Department of Pediatrics
4Child Health Institute of New Jersey
Rutgers Robert Wood Johnson Medical School
New Brunswick, NJ 08901, USA
Corresponding author:
Derek B. Sant’Angelo
The Child Health Institute of New Jersey
Rutgers Robert Wood Johnson Medical School
89 French St.
New Brunswick, NJ 08901
732-235-9394
santandb@rwjms.rutgers.edu
SUMMARY
The innate-like functions of NKT cells, including rapid production of effector cytokines, are controlled by the transcription factor PLZF (promyelocytic leukemia zinc finger; zbtb16). Conventional T cells that ectopically express PLZF spontaneously acquire an activated, effector phenotype. Therefore, while expression of PLZF is critical for NKT cell function, specific inactivation of the gene appears to be equally important for the prevention of de novofunctionality in conventional T cells. Activation induced expression of lineage defining transcription factors such as T-bet, FoxP3, RORgd, GATA3 and others is essential for na？ve T cell differentiation into effector T cells. In this study, we used sensitive genetic-based approaches to assess induction of PLZF expression in conventional T cells. We found that PLZF was stably repressed in non-innate T cells starting early in thymic development. The inactivated state is stably maintained in mature T cells, even under the inflammatory conditions imposed by bacterial infection.