[대학원 생명과학과 세미나 안내]
연사 : 김민수 교수 (University of Rochester Medical School)
연제 : Shining light on immunity
일시 : 2017년 5월 15일 (월) 오후 5시
장소 : 하나과학관 A동 101호
초청교수 : 유상동 교수
Abstract
1. Inflammatory cues regulating effector CD8 T cell recruitment
The efficient trafficking of activated effector T cells into peripheral non-lymphoid tissues is key to enact their protective functions. Despite considerable advances in the understanding of T cell trafficking in secondary lymphoid organs, the real-time recruitment of T cells into target tissue sites is not well characterized. Using Multiphoton-intravital microscopy (MP-IVM), we test our hypothesis that the diversity in the local tissue milieus created by the early innate responses provides a combinatorial mechanism for generating both specificity and flexibility in T cell-endothelial cell interactions and transmigration in vivo.
2. Optogenetically engineered T cells for cancer immunotherapy
Adoptive cell transfer (ACT) utilizing CAR (chimeric antigen receptor)-expressing T cells has been one of the most effective immunotherapies against hematological malignancies, but the significant clinical success is not yet achieved in solid tumors due to strong immunosuppressive local tumor microenvironment; (1) impaired trafficking of T cells to tumor sites, (2) strong immunosuppressive tumor microenvironment, and (3) off-target cytotoxicity. Optogenetics is a technique that uses a combination of techniques from “optics” and “genetics” to control defined cellular processes by controlling genetically modified light-sensitive proteins using optical stimulation. The goal of the research is to develop and demonstrate new optogenetic approaches to overcome those three recognized barriers in CAR T cell therapy.