[대학원 생명과학과 세미나 안내]
연사 : Titus Boggon 교수(Yale University)
연제 : Signaling from Rho GTPases to actin
일시 : 2017년 6월 26일 (월) 오전 11시
장소 : 하나과학관 A동 207호
초청교수 : 송현규 교수
Abstract
Rho GTPase signaling cascades are critical for cytoskeleton organization, cell morphology, cell motility and cell cycle. Although these pathways have been studied for over 30 years there are still significant gaps in our understanding of how they are regulated. My laboratory is interested in discovering these basic molecular level mechanisms of control. We are taking a ‘whole pathway’ approach that targets key upstream regulators and downstream effectors of Rho GTPases, and are focusing on specific discrete topics that will resolve fundamental gaps in the knowledge of Rho pathway signal regulation. A central topic of our research is to resolve major outstanding questions of how Rho cascades are regulated/dysregulated. We have done this by (a) discovering the autoregulation mechanism for a class of Rho effector kinase, (b) defining the molecular basis how Rho signaling controls actin depolymerization via a unique kinase-substrate interaction, and (c) defining the molecular basis for serine-threonine kinase phosphoacceptor specificity. I will present these studies.