[대학원 생명과학과 세미나 안내]
연사 : 박지용 교수(광주과학기술원 생명과학부)
연제 : Disease Specific Protein Signaling Network Analysis by Mass Spectrometry
일시 : 2017년 7월 19일 (수) 오후 3시
장소 : 하나과학관 A동 101호
초청교수 : 송현규 교수
Abstract
Protein phosphorylation is a well-known posttranslational modification involved in many important biological processes including cellular signal transduction. More than one third of proteins in biological systems are expected to be phosphorylated. Cellular protein phosphorylation events are tightly regulated by specific kinases and phosphatases. Abnormal or aberrant protein phosphorylation events have been implicated in various diseases.
Recent developments in quantitative proteomics including phosphopeptide/phosphoprotein enrichment methods and mass spectrometry have revealed many protein phosphorylation events involved in the developments of various types of diseases. These protein phosphorylation events could be the causes or the outcomes under specific disease conditions.
In this presentation, we will demonstrate how our newly developed proteomics approach can be used to screen crucial protein phosphorylation events in the development and progression of various diseases.