[대학원 생명과학과 세미나 안내]
연사 : 오구택 교수(이화여자대학교 생명과학과)
연제 : The Role of Peroxiredoxins in Autophagic Flux in the Pathogenesis of Atherosclerosis
일시 : 2017년 11월 28일 (화) 오후 7시
장소 : 하나과학관 A동 101호
초청교수 : 최의주 교수
Abstract
Reactive oxygen species (ROS), which include superoxide anions and peroxides, induce oxidative stress, contributing to the initiation and progression of cardiovascular diseases involving atherosclerosis. The endogenous and exogenous factors hypercholesterolemia, hyperglycemia, hypertension, and shear stress induce various enzyme systems such as nicotinamide adenine dinucleotide (phosphate) oxidase, xanthine oxidase, and lipoxygenase in vascular and immune cells, which generate ROS. Besides inducing oxidative stress, ROS mediate signaling pathways involved in monocyte adhesion and infiltration, platelet activation, and smooth muscle cell migration. A number of antioxidant enzymes (e.g., superoxide dismutases, catalase, glutathione peroxidases, and peroxiredoxins) regulate ROS in vascular and immune cells. Atherosclerosis results from a local imbalance between ROS production and these antioxidant enzymes. In this lecture, I would like to discuss 1) ROS-dependent atherogenic signaling in endothelial cells, macrophages, and vascular smooth muscle cells, and 2) roles of peroxidases in autophagic flux.