[대학원 생명과학과 세미나 안내]
연사 : 김양미 교수(건국대학교 시스템생명공학과)
연제 : Dynamics of proteins in relation to their functions: Application of NMR spectroscopy to study protein motion
일시 : 2018년 5월 4일 (금) 오후 5시
장소 : 하나과학관 A동 B131호
초청교수 : 김충호 교수
Abstract
Flexibilities in protein conformations are essential for their functions, playing key roles in molecular recognition, rate-limiting conformational transitions, and catalysis. Information on the structure of proteins should be complemented by the information on their motion, both to characterize the protein and to understand its function. The relationship between protein structure, dynamics, and function is very challenging to study because the conformational space available to a protein is extensive and the time scales of conformational motions range widely, from picoseconds to seconds. These time scales are accessible by solution NMR making it a suitable technique for investigating the motions in proteins. The NMR spin relaxation methodology and case studies of selected proteins to show examples of protein dynamics that are closely related to their function will be introduced in this seminar. The importance of dynamic features of proteins for their molecular recognition processes and the catalytic activities of enzymes is demonstrated using spin relaxation approaches, showing that solution NMR spectroscopy is a unique tool for studying protein dynamics.