[대학원 생명과학과 세미나 안내]
연사 : Youssef Belkhadir 박사(Gregor Mendel Institute (GMI))
연제 : The plant immune system constrains bacterial attempts to remain motile while staying undetected
일시 : 2019년 10월 30일 (수) 오전 11시
장소 : 하나과학관 A동 207호
초청교수 : 김옥매 교수
Abstract
Plants sense and respond to microbes with an arm of the plant immune system that relies on the detection of microbial-associated molecular patterns (MAMPs) by cell surface pattern-recognition-receptors (PRRs). Stereotypical MAMPs include several epitopes derived from flagellin molecules, the building-block of bacterial flagella. In Arabidopsis, the PRR FLAGELLIN-SENSING 2 (FLS2) detects a highly conserved 22-amino acid epitope (flg22) from the N-terminus of flagellin. flg22 is evolutionary conserved and mutations of conserved amino acids that subvert immune receptor detection have deleterious effect on flagellar function and bacterial motility. Here, we set out to define how tradeoffs between motility and host recognition have been molecularly balanced throughout evolution. To circumvent the shortcoming of working in a limited flg22 natural evolutionary space, we artificially evolved >1000 flg22 variants and tested their interaction with FLS2. We will present work defining the molecular constrains and associated mechanisms that have impinged on bacterial attempts to evade immune system activities while remaining motile.