[BK 생명과학과 세미나 안내]
연사 : 심지원 교수(한양대 생명과학과)
연제 : Hematopoiesis and Immunity in Drosophila
일시 : 2022년 01월 27일 (목) 오전 11시
장소 : 온라인 화상 강의로 진행됩니다.
초청교수 : 이은진 교수
**Zoom 회의 참가
https://korea-ac-kr.zoom.us/j/89331780922?pwd=WGhhREU2aTRWcDZsbnE4OXpQR0dBZz09
Abstract
Drosophila hemocytes are akin to mammalian myeloid blood cells and function in stress and immune-related responses. Hemocytes give rise from a multipotent progenitor population, which respond to intrinsic, paracrine or juxtacrine signals to determine the number of functional blood cells during conventional conditions and during various environmental insults. Although various evidence supports the intricate communication between the nervous system and the immune system, particularly in the setting of human bone marrow, the molecular basis for the inter-organ communication has not been comprehensively understood. Previous studies have shown that nutrition or olfactory sensation systemically control the differentiation of myeloid progenitors via insulin or GABA, respectively, secreted from specific brain neuroendocrine cells. These signals are modified by the external environment and relayed directed information from a distant organ, the brain, to the blood cells through systemic signaling components. Recent studies of our own have identified additional inputs that can modify the myeloid progenitors or innate immune reactions. In this seminar, I will introduce our recent findings on the systemic regulation of blood cell differentiation and non-immune functions of blood cells, and recent studies on various organ to organ interactions. Given the high conservation rate between humans and flies, it is likely that mechanisms found in flies are conserved in higher vertebrates including humans.